Replenish 360’s IV Hydration Therapy IV hydration therapy, also known as intravenous hydration therapy or IV drip, is a medical procedure that delivers fluids, electrolytes, and nutrients directly into a patient's bloodstream through a vein. The therapy is often used to treat dehydration, electrolyte imbalances, and other conditions that require rapid rehydration.During IV hydration therapy, a healthcare provider inserts a thin needle into a vein, usually in the arm, and connects it to an IV bag filled with a solution that is tailored to the patient's specific needs.